Never had a problem with the weapons in FF7, of course, by the time I fought them, what they would've given me was essentially useless (I had gotten the Gold Chocobo and a god materia setup...)
Omega Weapon in FFX was another easy one, I had a big problem with this shell monster that you fight at the Chocobo field (You have to catch monsters to make the guy make him.) because I'd beat him down, then he'd up and go back into his shell, and regen 200K HP a turn! Needless to say, I set myself up with Ultima and doublecast, and spammed the hell out of him till he dropped.
But the hardest boss, for me, by far, was Neo Granzone in Super Robot Wars 3, Aside from him having 65K HP and getting better at stopping your attacks as you damage him, he also has 2 other guys, who were the bosses of the previous level! Its a tactical RPG mind you, so when I moved in my guys to beat him down, he fired off a area effect spell... twice! It blasted like 80% of my guys!
