I didn't see any mention of this one, but I may have skipped over it by mistake. Those who have played Star Ocean 2 will know who I'm referring to:
THE ISCERA QUEEN!! @#$###@@#@!@!!!!!!!
After a good solid hour of pounding her with four lvl 255 characters she STILL did not die and managed to kill all four characters almost simaltaneously (or at least within four to five seconds) with ONE MOVE!!!! ARRRGGGHHHHHHHH!!!!!!! Ugh. I still haven't beaten her.