Well, for me it's not just about Mega Man at this point. That's just the straw that broke the camel's back.
Phoenix Wright fans have been given the shaft recently. It's quite possible we won't see this franchise outside of JPN anymore. Which saddens me greatly. Guess I'm going to have to learn Japanese at some point.
Resident Evil has been on a decline (subject to opinion, I preferred it when it had any kind of horror in it, something RE4 did still have at certain points) and while a spin-off, Operation Raccoon City is not helping the action approach the series has been favoring. I have my eye on Revelations though.
I'm not sure what's up with Monster Hunter. They're refusing to localize Portable 3rd overseas, and I hope that won't become a trend (like Phoenix Wright).
Devil May Cry used to be my favourite series (not just from Capcom). I'm not even sure what they're trying to do with DmC (aside from trying to troll 5 million copies off of consumers apparently), but this is subject to opinion as well. As it is now, the game plays horribly slow, with zoom effects and hit-slowdowns... it seems more akin Heavenly Sword than Devil May Cry. Which, I guess, is not all that surprising considering the developer.
Then there's the other things that have been piling up for years now. Mainly things like the lack of a new God Hand, Dino Crisis, Dark Stalkers, Onimusha, Power Stone, Strider, Clock Tower-- etc. They're just mainly focusing on their Fighting franchises right now (which are selling pretty good last I heard, so hey) and taking little risks. The whole within-a-year expansion of Marvel Vs Capcom 3 is outrageous as well, if you ask me.
Though not to be a total downer, on the plus side dragon's Dogma looks good and CyberConnect2's Asura's Wrath looks badass as well.