Vista hates all things audio...that's the only real problem I've found. Otherwise I've NEVER had a problem, and my hardware isn't even all that great...
It DID come with free 512MBs of RAM when I bought it, though...and that helped a LOT, lol.
And, to Dyne, the only reason I use my MacBook more frequently now is because it plays WoW at Max settings, and all my addons, with 40FPS, I like Adium better than Trillian, and my MacBook can handle my iTunes library where as NOTHING on my PC can handle my music library over there...