My own experiences say the opposite. So many times, I've read people saying they won't listen to a remix of a game they've never played, or listen to a game's soundtrack for the same reason. That reason, as I've seen it put, is that there's no nostalgia factor for them... that they have no connection to it. Meanwhile, a considerable majority of those who played NES games, have played the MegaMan games, the Castlevania games, the Zelda games (except me), the Contras, etc.
Again, this is from my own experiences.