As always Rozo is the master!
Just want to clarify something.
Panning hard/soft/fantastic, record/write 2-100 different tracks, doesn't necessary makes your gtrs "ring out clearly".
Actually you can make one single guitar track sound "ring out clearly".
Synth/samples stuff works in a different way, they sounds "ring out clearly" from the begining.
This makes sense if we remember the question: " both in stereo and mono?"
All you need is to focus at amp and cabinet settings, but don't forget about drums and bass. The trick is that the bass and drums make ~30% of your guitar sound.
In other words, if bass sounding doesn't fit the gtr, so as and drums, you'll have a disbalance in your soundscape. Buried gtrs/bass/drums or other unpleasant stuff.
Sorry for my english, if i said something wierd.