Do you mean in terms of how well the music will be recieved? because if so, i think its just a crapshoot with alot of variables involved.
BUT, in favor of it anyways, if you remix a soundtrack for something thats not done before, 1. thats super cool because its unexplored musical territory and 2. guaranteed, someday, somewhere, youll make at least ONE persons day because you remixed a song from a game they loved.
DO IT.