I stumbled across this webcomic a few days ago and I've literally been addicted to it ever since I started reading.
What really sets this webcomic apart from most others is the way the author incorporates animated gifs, simple flash games, as well as REALLY well done flash movies with an amazing soundtrack to boot. It really feels like an actual webcomic (as it wouldn't be possible to retain the same format in any other medium), rather than just a comic that happens to be on the internet.
In addition, the format in which the comic is presented is based on old text-based adventure games where the player would issue commands to the ingame characters by typing them out. This idea is retained in the form of a suggestion box where readers can post their commands for the characters, with the author generally picking the best/most interesting ones to advance the plot without incorporating too many tangents (except the most funny ones).
The art is extremely charming, generally using a sort of super-deformed style, but switching appropriately to more realistic proportions for the characters during action sequences.
Then there's the writing, which is arguably the best part in my opinion. The overall plot gets extremely complex, with multiple timelines and universes running through each other, but somehow the author makes it all work and manages to keep things relatively coherent. The plot contains many elements from games like Earthbound (Homestuck is even somewhat of a synonym for Earthbound), The Sims, Spore, and Chrono Trigger, as well as a shitton of other pop-cultural shoutouts (too many to list).
The characters are all quite detailed and well written, despite the sizable cast. I honestly can't think of a single character I outright dislike, and the dialogues all tend to be very witty and intelligent, without feeling overly pretentious.
Oh, and the comic gets updated like 5 times a day, unless the next update is some big flash movie.
TL;DR GO READ THIS NOWbluh bluh