Mixing needs some more work. Drums and rhytm guitar completely drown the rest of the instruments. Cymbals for example are very loud.
The first section (Ryoshima) sounds very muddy, I can barely identify what the rhytm guitar is playing. Strings are completely drowned in that section by the way. Flute in 0:42 plays a wrong note!
I'm not sure I like the lead tone. I think it would sound better with a bit of a softer tone, this one is too agressive and doesn't blend that well with the flute. The solo also sounds a bit dirty, but I believe that is more because of the mixing rather than the playing.
Arrangement is good, the blend of the different themes is seamless and you picked many of Okami's best themes. The switch to Reset is very good!
With better mixing this would be a pretty good song. Try to balance the rhytm sections better and give some space for the leads to shine!
Also, the change to clean guitars in the ending is great. In fact, I'd love it if you inserted more of this type of changes into the rest of the song