I tried MP as germans right away with one other person as Egypt. Me and him were on the same team. First thing he does is trespass on every single city state he comes across until they all get so pissed that each city state declares permanent war on our team. This of course gets the other actual civs to declare war on us too because they all give the destroy Egypt quest. He starts laughing and comments on how if this was Civ IV I'd have a deathstack of units heading for my city right now. He's sitting on a defensible peninsula, and I'm pretty much in the middle of the continent.
The AI focuses on him though, and I muster up a couple units and attack England. Unfortunately I start running really low on money.(Not used to the economy yet) I propose a trade with Egypt and he gives me a city instead saying better to have a gold mine than gold...and my debt gets worse and I lose a unit to debt. He starts laughing again, and I go to diplomacy, make peace with one of the teams, and trade the city to Japan for money...who promptly razes the city much to his dismay. Before I could continue attacking England though, the game stuck at waiting for other players.(And neither of us had a turn) Was a hilarious first game. Though pretty confusing at first.
I have a single core 2.4 GHz processor and 2.5 GB of RAM and it's not bad. Turns take a bit long sometimes(About 20 seconds at most)