Pretty much with all my drums, I make a pattern in FL Studio (usually 8 - 16 beats), copy, paste, and make each pattern unique as I see fit. No reason to separate or mix and match unless it's a layered sound on top of the drum set (like an extra hat or snare or something), just so I can keep patterns from looking too complicated. I'd love to get a drumset to just play a midi drums all the way through. That'd be fun and much easier.
I don't see any problem for what you said Dan unless you're going for a straight up live sound. It's pretty common in studio mixes to layer drums, though, especially if you don't intend to play it for audiences.
However if you're doing something that would require a 7 handed drummer, that IS pretty insane. Lol.